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在mesenchymal stem cell therapy這個產品中，有2篇Facebook貼文，粉絲數超過2萬的網紅國家衛生研究院-論壇，也在其Facebook貼文中提到， ➥間質幹細胞(MSC)具有廣泛的免疫調節特性，已應用於再生醫學及免疫或發炎性疾病，包括異體移植。 COVID-19在短時間內造成高死亡率的大流行主因是肺損傷及呼吸窘迫症候群；由於目前沒有有效的預防或治療方法，儘管缺乏臨床數據，間質幹細胞療法(MSCT)已成為一種可能的候選療法。 ...

mesenchymal stem cell therapy 在 國家衛生研究院-論壇 Facebook 的最佳解答

國家衛生研究院-論壇 By 國家衛生研究院-論壇

2020-08-21 13:30:00 有 17 人按讚
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➥間質幹細胞(MSC)具有廣泛的免疫調節特性，已應用於再生醫學及免疫或發炎性疾病，包括異體移植。


COVID-19在短時間內造成高死亡率的大流行主因是肺損傷及呼吸窘迫症候群；由於目前沒有有效的預防或治療方法，儘管缺乏臨床數據，間質幹細胞療法(MSCT)已成為一種可能的候選療法。


最早MSCT在肺部免疫或發炎性疾病的實驗室數據可追溯至2003年，2004年首次應用MSCT於「移植物對抗宿主疾病」的治療；自此之後，已有大量實驗室數據顯示MSC對免疫調節的用處，目前有超過1/3的MSCT臨床試驗是針對免疫或發炎性疾病。


MSCT的實驗室數據在非傳染性疾病，如慢性阻塞性肺病、氣喘、及肺纖維化，及細菌傳染之免疫及發炎性疾病，通常顯示具治療效果，但在病毒感染之肺部疾病，其實驗室數據少且不一致。本文作者描述MSC在肺部免疫或發炎性疾病的臨床應用理論，並整理了正在進行中的MSCT臨床試驗(包括COVID-19)，提出MSCT在COVID-19上可能的應用。( 財團法人國家衛生研究院 莊淑鈞博士摘要整理，完整文章，詳：http://forum.nhri.org.tw/covid19/virus/j_translate/j1844/)


📋 Stem Cells Translational Medicine - 2020-06-11
Current status of mesenchymal stem cell therapy for immune/inflammatory lung disorders: Gleaning insights for possible use in COVID-19
■ Author：B Linju Yen, Men-Luh Yen, Li-Tzu Wang, et al.
■ Link：https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.20-0186


〈 國家衛生研究院-論壇 〉
➥ COVID-19學術資源-轉譯文章 - 2020/08/21
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近年台灣面臨人口老化、少子化、人口移動頻繁、貧富差距的社會現象，為因應此現象，政府成立衛生福利部，以有效彙整醫藥衛生與社會福利之資源與服務，提供整合性的服務措施及全方位的照護體系，給予民眾多方向的全人服務。完整說明，詳：https://bit.ly/3bjItNv )
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mesenchymal stem cell therapy 在 Dr 文科生 Facebook 的精選貼文

Dr 文科生 By Dr 文科生

2020-08-07 18:00:02 有 995 人按讚
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《原來臍帶除了臍帶血還有臍帶膜？》

有不少讀者都對臍帶的醫療用途有興趣，上回跟大家分享完臍帶血後，今日跟大家講講比較少人聽過的「臍帶膜」。

上回提到過去小Baby出生後，臍帶大多被當做醫療廢物，在過去的三十年臍帶血持續發展，透過幹細胞治療血液類疾病。而近年，除了臍帶血外，科學家發現了原來臍帶外層的膜（Lining）也有潛在的醫療用途。

【何謂臍帶膜（Umbilical Cord Lining Membrane）】

在講解臍帶膜前，先講解一下臍帶的歷史背景。

17世紀英國醫學家Thomas Wharton發現臍帶組織（Stroma）含有一種啫喱狀的物質，將其命名為Wharton's jelly。這層啫喱的作用為防止臍帶血管（靜脈和動脈）交叉（clumping）和提供臍帶的彈性。1991年科學家McElreavey從Wharton's jelly中分離出類似纖維母細胞的細胞（Fibroblast-like cells）[1]，而這些Fibroblast-like cells在2004年被發現是幹細胞的一種 - 間質幹細胞（Mesenchymal Stem Cells MSCs） [2]。自此臍帶不同的組織便成為科學家的研究對象。

隨著臍帶研究的發展，近年科學家發現能夠利用CellOptimaTM 技術從臍帶外層的組織（臍帶膜）裡提取更多的幹細胞 - 除了間質幹細胞（Mesenchymal Stem Cells MSCs）外，還可提取上皮幹細胞（Epthelial Stem Cells EpSCs）［3］。

那麼，這些EpSCs和MSCs幹細胞跟臍帶血的造血幹細胞（Hematopoietic Stem Cells HSCs）有什麼分別呢？

臍帶血的造血幹細胞主要作用是生成為不同的血液細胞，如之前文章提及到的紅血球、白血球和血小板，可用作治療個別血液類疾病如血癌和個別免疫系統疾病。

MSCs幹細胞則可生成為一些組成不同器官如皮膚、軟骨組織、腦部、心臟和肌肉等等的細胞。

EpSCs幹細胞則可生成為一些組成皮膚或空心（Hollow Structure）的器官如腸臟、氣管、膀胱和子宮等等的細胞。

由於MSCs跟EpSCs幹細胞有生成作不同器官的潛能，近年不少科學家紛紛收集臍帶進行研究。

研究發現MSCs幹細胞有以下潛能並正在對這些疾病進行動物實驗和臨床試驗。[4]

1. 心血管疾病如心肌梗塞和心肌無力症
2. 腦神經系統疾病如腦退化症、多發性硬化症和脊柱神經受傷等等
3. 自體免疫系統疾病如一型糖尿病、自體免疫性肝炎、潰瘍性結腸炎、紅斑狼瘡和類風濕性關節炎等等

令人鼓舞的是，根據目前的臨床試驗公怖結果，在自體免疫系統疾病和內分泌疾病方面，移植MSCs幹細胞後，病情有顯著的改善。同時有研究亦發現MSCs幹細胞有較低的免疫原性（Immunogenicity）、相當較能避開人體免疫系統的識別，減低移植排斥反應。現時不少的臨床研究制用此特性，探討將MSCs幹細胞用作異體移植（Allogeneic Transplantation）例如近親甚至免疫不相容（HLA-Mismatch）的外人等[8]， MSCs幹細胞的移植技術的研究開始了二十多年，目前的研究成果相當正面，其低免疫原性的特質在未來能夠怎樣應用在免疫不相容的病人身上實在值得我們期待。[2][5][8]

而EpSCs幹細胞方面，研究發現或許有以下潛在臨床應用 [6][7]

1. 燒傷治療和傷口癒合
2. 一型糖尿病
3. 肝臟衰竭

不過由於有關臍帶膜的研究，並不被歸納為醫療系統常用的治療，現有的應用均為實驗性質。雖然目前研究仍處床試驗階段，但隨著移植的個案越來越多，臍帶膜的幹細胞似乎有著不少的發展潛力。

跟上回提到臍帶血一樣，從收集臍帶膜到儲存臍帶膜及臨床實驗性應用都有嚴謹的要求，例如運送的時間、過程、儲存系統以及國際認證。

近年不少提供臍帶血儲存服務的生物科技公司同時有提供儲存臍帶膜的服務[2]。跟臍帶血一樣，目前並非醫療系統會資助的常見項目，故對一般家庭來可謂一筆大開支。

正在考慮儲存臍帶血或膜的孕婦宜先充分調查不同臍帶生物科技公司的背景、財政狀況、過去的移植紀錄、使用的儲存技術等等。同時，如有任何疑問務必諮詢專家或醫生意見以作informed decision。

【Reference】
[1] Isolation, Culture and Characterisation of Fibroblast-Like Cells Derived From the Wharton's Jelly Portion of Human Umbilical Cord. Stem Cell Biochemical Society Transaction. https://portlandpress.com/biochemsoctrans/article/19/1/29S/81930/Isolation-culture-and-characterisation-of

[2] The Therapeutic Potential, Challenges and Future Clinical Directions of Stem Cells From the Wharton's Jelly of the Human Umbilical Cord. Stem Cell Reviews and Reports. https://link.springer.com/article/10.1007/s12015-012-9418-z

[3] Epithelial and Mesenchymal Stem Cells From the Umbilical Cord Lining Membrane. Cell Transplant.
https://pubmed.ncbi.nlm.nih.gov/24636188/

[4] Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy. Stem Cells international. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019943/

[5]Immunogenicity and Immunomodulatory Properties of Umbilical Cord Lining Mesenchymal Stem Cells. Cell Transplant. https://pubmed.ncbi.nlm.nih.gov/21054940/

[6] Short review on human umbilical cord lining epithelial cells and their potential clinical applications. Stem Cell Research & Therapy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634865/#CR40

[7] Longitudinal In-Vivo Volumetry Study for Porcine Liver Regeneration From CT Data. 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. https://ieeexplore.ieee.org/document/6944684

[8] The Importance of HLA Assessment in “Off-the-Shelf” Allogeneic Mesenchymal Stem Cells Based-Therapies. International Journal of Molecular Sciences. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888380/

Photo: Internet Photo

#研究分析 #科普系列 #臍帶膜 #上皮幹細胞 #間質幹細胞 #CellOptima #MesenchymalStemCells #EpthelialStemCells

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“This is not a drug but a method which uses mesenchymal stromal cells (MSC) to treat coronavirus (patients),” Kianoush Jahanpour said on ...

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Stankiewicz said the most popularized form is Mesenchymal stem cells (MSCs), which are defined as cells that have the ability to self-renew ...

#67. Clarkson University Chemical & Biomolecular Engineering ...

Her project, "Investigating the Fundamental Interactions between Mesenchymal Stem Cells and Hydrogels – Towards a Stem Cell-Biomaterial Therapy ...

#68. Stem Cell Therapy - Alzheimacy - Creative BioMart

In addition, genetic modification of NSCs with improved function also has a good effect on the treatment of AD. Mesenchymal stem cells (MSCs): MSC is regarded ...

#69. Review of 4 cell therapy types under study for COVID-19

Four of the major cell therapies that are presently undergoing trials for COVID-19 are mesenchymal stem/stromal cells (MSCs), natural killer ...

#70. Kansas COVID stem cell research bill divides KU Med ...

Sen. Mike Thompson, R-Shawnee and a member of the center's advisory board, said the treatment would target end-stage COVID inflammation "that ...

#71. Mesenchymal stem cell extracellular vesicles mitigate vascul...

Novel therapies that target gut injury and vascular permeability early after HS/T could have substantial impacts on trauma patients. In this study, we ...

#72. Mesenchymal stem cell-based treatments for COVID-19

MSC mechanisms of action involve differentiation potentials, immune regulation, secretion of anti-inflammatory factors, migration and homing, ...

#73. Engineered cells successfully treat cardiovascular and ...

... the way for developing less expensive cellular therapies to treat ... of more cost-effective cell therapy using 'universal' stem cells.

#74. Microcarrier-Based Bioreactors Can Make More Stem Cells

... offers many advantages in growing human mesenchymal stem cells. ... Ang-Chen Tsai, PhD, senior scientist at WuXi Advanced Therapies, ...

#75. Improving Mesenchymal Stem Cell Therapies with TSG‐6

The general lack of clinical effectiveness of mesenchymal stem cell (MSC) therapy may derive from cellular heterogeneity in the transplanted ...

#76. Mesenchymal Stem Cells Mexico - Regenamex

in Mexico, providing human stem cells for clinical and commercial applications worldwide, offering the most advanced non-surgical stem cell therapies and blood ...

#77. Sonic advance: How sound waves could help regrow bones

The innovative stem cell treatment from RMIT researchers offers a smart way forward for overcoming some of the field's biggest challenges, ...

#78. Ep. 212: "Development of the Heart, Lung, and Vasculature ...

Her lab's goal is to develop novel therapies for the regeneration of ... Single Cell Sequencing with Fewer Cells – Scientists developed a ...

#79. Sonic advance: How sound waves could help ... - Newswise

Researchers have used sound waves to turn stem cells into bone cells, ... The innovative stem cell treatment from researchers at RMIT ...

#80. Mesenchymal Stem Cell Therapy - 第 433 頁 - Google 圖書結果

Subbanna PK (2007) Mesenchymal stem cells for treating GVHD: in-vivo fate and optimal dose. Med Hypotheses 69:469 Prather WR, Toren A, Meiron M (2008) ...

#81. Stem Cells May Boost Myelin Production in CMT1A, Study ...

Mesenchymal stem cells were found to boost myelin-producing Schwann ... The therapeutic benefits of MSCs, which can give rise to many other ...

#82. Home - MSC Home

An educational website on information about and regarding mesenchymal stem cells (commonly referred to as, "MSCs").

#83. Can stem cells help with multiple sclerosis? - Sharenol

What are mesenchymal stem cells (MSC)?; 17. Is stem cell therapy a new multiple sclerosis breakthrough ...

#84. Exosome as a target for cancer treatment - Journal of ...

In contrast, the use of stem cells in cancer treatment is a ... As a result, it is possible to infer that MSC-derived exosomes can suppress ...

#85. CANCER STEM CELLS : SECRET OF FAILURE - DergiPark

Key Words: Cancer stem cell (CSC); Drug Resistance;. Therapy ... role in epithelial to mesenchymal transition11.

#86. Stem Cells Market Analysis by Current Industry Status ...

Stem cell therapies have revolutionized the treatment of ... Neuronal stem cells; Mesenchymal stem cells; Hematopoietic stem cells ...

#87. Can stem cell therapy recover the function of the kidney from ...

Mesenchymal stem cells derived from a person's fat cells may help repair kidney damage caused by narrowing blood vessels, Mayo Clinic research has ...

#88. Operational Highlights and Financial Results for the Period

Mesenchymal stromal cell therapy induces high responses and ... bone marrow derived mesenchymal stem cell product, for the treatment of ...

#89. Safety, Efficacy and Mechanisms of Action of Mesenchymal ...

Cryopreserved or fresh mesenchymal stromal cells: only a matter of taste or key to unleash the full clinical potential of MSC therapy? Adv Exp Med Biol.

#90. Research at Uppsala University - Uppsala University, Sweden

Human mesenchymal stem cells (MSCs) have been proposed as the epitome ... on the clinical application of these cells, albeit current MSC treatments .

#91. Global Cell Freezing Media for Cell Therapy Market 2021 ...

The study examines all of the key issues in depth. Human Embryonic Stem Cells; CAR-T Cell Therapy; Neural Stem Cell Therapy; Mesenchymal Stem ...

#92. Allogenic Cell Therapeutics: Successfully Creating Master ...

Waisman Biomanufacturing — whose cell therapy services include work with mesenchymal stromal cells (MSCs), human embryonic stem cell (hESC) banks, ...

#93. HIPI: Home

In utero treatment of myelomeningocele with allogenic umbilical cord-derived mesenchymal stromal cells ... Stem cells biotechnologies, Curr Res Transl Med.

#94. Rheumatoid Arthritis Stem Cell Therapy Market Size, Growth ...

Allogeneic Mesenchymal Stem Cells · Bone Marrow Transplant · Adipose Tissue Stem Cells.

#95. Rheumatoid Arthritis Stem Cell Therapy Market Size ...

The Rheumatoid Arthritis Stem Cell Therapy report shows the likely direction of the ... By Product Type (Allogeneic Mesenchymal Stem Cells, ...

#96. What's new | European Medicines Agency

25/02/2022, Orphan designation: Autologous CD34+ cells transfected ... peripheral blood-derived mesenchymal stem cells, 16/02/2022, Positive.

#97. Cancer Biology | bioRxiv

... stem cells express non-canonical proteins and exclusive mesenchymal-like or ... attenuates epithelial ovarian cancer sensitivity to cisplatin therapy.

#98. The state of longevity – 2021's Who's Who in age-related ...

The therapy used led to a reduction in glucose, leading towards body ... Longeveron's phase 2b study of Longeveron Mesenchymal Stem Cells ...